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Histomorphometric analysis following augmentation of the posterior mandible using cancellous bone‐block allograft
Author(s) -
Nissan Joseph,
Marilena Vered,
Gross Ora,
Mardinger Ofer,
Chaushu Gavriel
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33096
Subject(s) - cancellous bone , mandible (arthropod mouthpart) , implant , connective tissue , medicine , materials science , biocompatible material , dentistry , anatomy , biomedical engineering , surgery , pathology , biology , botany , genus
The present study was conducted to histologically and histomorphometrically evaluate the application of cancellous bone‐block allografts for the augmentation of the posterior atrophic mandible. Twenty‐four consecutive patients underwent augmentation with cancellous bone‐block allografts in the posterior mandible. A bony deficiency of at least 3 mm horizontally and/or vertically according to CT para‐axial reconstruction served as inclusion criteria. Following 6 months, 85 implants were placed and a cylindrical sample core was collected. All specimens were prepared for histological and histomorphometrical examination. Implant survival rate was 95.3%. Follow‐up ranged 12–66 months (mean 43 ± 19 months). The mean newly formed bone was 44 ± 28%, that of the residual cancellous bone‐block allograft 29 ± 24%, and of the marrow and connective tissue 27 ± 21%. Statistically significant histomorphometric differences regarding newly formed bone (69% vs. 31%, p = 0.05) were found between younger (<45 years) and older (>45 years) patients, respectively. Histomorphometric differences regarding residual cancellous bone‐block allograft (17% vs. 35%) and of the marrow and connective tissue (14% vs. 34%) were not statistically significant. Cancellous bone‐block allograft is biocompatible and osteoconductive, permitting new bone formation following augmentation of extremely atrophic posterior mandible with a two‐stage implant placement procedure. New bone formation was age‐dependent. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: , 2011.