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Scaffold‐based approach to direct stem cell neural and cardiovascular differentiation: An analysis of physical and biochemical effects
Author(s) -
Chew Sing Yian,
Low Wei Ching
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33064
Subject(s) - scaffold , stem cell , neural stem cell , neuroscience , materials science , regeneration (biology) , stem cell therapy , cellular differentiation , regenerative medicine , biomedical engineering , biology , nanotechnology , microbiology and biotechnology , medicine , biochemistry , gene
Although stem cell therapy holds tremendous promise in tissue regeneration and disease treatment, its full potential may only be realized through the thorough understanding and capability in specifically directing stem cell fate commitment. A scaffold‐based approach of imparting physical and biochemical cues appears to be a logical method in reconstructing the complex three‐dimensional configuration of stem cell niches. In fact, interest in this area has gained significant momentum over the recent years. This review summarizes and evaluates the recent outcomes of studies associated with a scaffold‐based approach to directing and understanding stem cell neural and cardiovascular differentiation. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2011.