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Salicylic acid‐derived poly(anhydride‐ester) electrospun fibers designed for regenerating the peripheral nervous system
Author(s) -
Griffin Jeremy,
DelgadoRivera Roberto,
Meiners Sally,
Uhrich Kathryn E.
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33049
Subject(s) - electrospinning , materials science , regeneration (biology) , scaffold , biomaterial , biomedical engineering , tissue engineering , nerve guidance conduit , nanofiber , schwann cell , neurite , biophysics , polymer , anatomy , nanotechnology , composite material , chemistry , microbiology and biotechnology , biology , in vitro , medicine , biochemistry
Continuous biomaterial advances and the regenerating potential of the adult human peripheral nervous system offer great promise for restoring full function to innervated tissue following traumatic injury via synthetic nerve guidance conduits (NGCs). To most effectively facilitate nerve regeneration, a tissue engineering scaffold within a conduit must be similar to the linear microenvironment of the healthy nerve. To mimic the native nerve structure, aligned poly(lactic‐ co ‐glycolic acid)/bioactive polyanhydride fibrous substrates were fabricated through optimized electrospinning parameters with diameters of 600 ± 200 nm. Scanning electron microscopy images show fibers with a high degree of alignment. Schwann cells and dissociated rat dorsal root ganglia demonstrated elongated and healthy proliferation in a direction parallel to orientated electrospun fibers with significantly longer Schwann cell process length and neurite outgrowth when compared to randomly orientated fibers. Results suggest that an aligned polyanhydride fiber mat holds tremendous promise as a supplement scaffold for the interior of a degradable polymer NGC. Bioactive salicylic acid‐based polyanhydride fibers are not limited to nerve regeneration and offer exciting promise for a wide variety of biomedical applications. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.