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Controlling cell growth on titanium by surface functionalization of heptylamine using a novel combined plasma polymerization mode
Author(s) -
Zhao Jing H.,
Michalski Wojtek P.,
Williams Catherine,
Li Li,
Xu HongSheng,
Lamb Peter R.,
Jones Scott,
Zhou Yan M.,
Dai Xiujuan J.
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33035
Subject(s) - materials science , osseointegration , biocompatibility , surface modification , titanium , plasma polymerization , adhesion , cell adhesion , biomedical engineering , osteoblast , polymerization , cell growth , nanotechnology , biophysics , chemical engineering , composite material , polymer , in vitro , implant , metallurgy , surgery , chemistry , biochemistry , medicine , engineering , biology
A novel bio‐interface, produced by a combined plasma polymerization mode on a titanium (Ti) surface, was shown to enhance osteoblast growth and reduce fibroblast cell growth. This new method can securely attach a tailored interface to difficult materials such as Ti or ceramics. Here a more stable and higher density of NH 2 functional groups is able to withstand sterilization in ethanol. The biocompatibility, in terms of cell attachment and actin cytoskeleton development, was markedly improved in vitro , compared with untreated Ti surfaces and samples treated by other plasma modes. It gave a boosted (approximately six times higher) cellular response of osteoblasts in their initial adhesion stage. These factors should increase the formation of new bone around implants (reducing healing time), promoting osseointegration and thereby increasing implantation success rates. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.