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In vitro and in vivo degradation of poly( D, L ‐lactide‐ co ‐glycolide)/amorphous calcium phosphate copolymer coated on metal stents
Author(s) -
Ma Xiaodong,
Oyamada Shizu,
Wu Tim,
Robich Michael P.,
Wu Hao,
Wang Xingwei,
Buchholz Bryan,
McCarthy Stephen,
Bianchi Cesario F.,
Sellke Frank W.,
Laham Roger
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33016
Subject(s) - materials science , amorphous calcium phosphate , plga , in vivo , composite number , copolymer , degradation (telecommunications) , polymer , amorphous solid , polyester , composite material , in vitro , nuclear chemistry , calcium , biomedical engineering , nanotechnology , nanoparticle , organic chemistry , chemistry , medicine , biochemistry , telecommunications , microbiology and biotechnology , computer science , metallurgy , biology
The purpose of this study was to optimize a novel biodegradable polymer for drug eluting stent (DES) applications. Degradation profiles of different poly( D, L ‐lactide ‐ co ‐glycolide)/amorphous calcium phosphate (PLGA/ACP) composites coated on stents were studied both in vitro and in vivo for three months. For the in vitro study, stents were immersed into the phosphate buffered saline (37°C, pH 7.4) with constant shaking. The polymer weight loss was measured weekly and morphological changes were analyzed. The results demonstrated that approximately 60% of polymer was degraded within the three‐month period and there was no significant difference between the different PLGA/ACP composites. However, the composite of 50% PLGA (65/35) with 50% ACP showed a slightly faster degradation rate than other composites. Morphologically, all stent surfaces changed from a micro‐porous before degradation to a corrugated solid micro‐net‐like structure at two months post degradation. Based on in vitro results, 65% PLGA (65/35) with 35% ACP) coated stents were selected and implanted into rat aortas ( n = 12) for the in vivo study. Microscopic observation showed that no composite was found on any of the implanted stents at 12 weeks post implantation, which indicated the selected PLGA/ACP composite is desired for DES applications. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: , 2011.