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The influence of surface energy of titanium‐zirconium alloy on osteoblast cell functions in vitro
Author(s) -
Sista Subhash,
Wen Cui'e,
Hodgson Peter D.,
Pande Gopal
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.33013
Subject(s) - materials science , x ray photoelectron spectroscopy , contact angle , surface energy , titanium alloy , titanium , alloy , scanning electron microscope , adhesion , osteoblast , zirconium , niobium , surface roughness , chemical engineering , energy dispersive x ray spectroscopy , surface finish , metallurgy , composite material , in vitro , chemistry , biochemistry , engineering
The success of an implant used for bone regeneration and repair is determined by the events that take place at the cell–material interface. An understanding of these interactions in vitro gives insights into the formulation of ideal conditions for their effective functioning in vivo . Thus, it is not only important to understand the physico‐chemical properties of the materials but, also necessary to assess the cellular responses to them to determine their long‐term stability and efficacy as implants. In the present study, we have compared the physico‐chemical and biological properties of titanium (Ti) and two Ti‐based alloys, namely: Ti‐ Zirconium (TiZr) and Ti‐Niobium (TiNb). The morphology, chemical analysis, surface roughness, and contact angle measurements of the alloys were assessed by scanning electron microscopy (SEM), X‐ray photoelectron spectroscopy (XPS), profilometer, and contact angle goniometer, respectively whereas the biological properties of the materials were evaluated by measuring the adhesion, proliferation, and differentiation of MC3T3‐E1 osteoblast cells on the surfaces of these alloys. Our results indicate that the biological properties of osteoblasts were better on TiZr surface than on TiNb surface. Furthermore, the surface energy and substrate composition influenced the superior biological activity of the TiZr alloy. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2011.