Premium
Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β‐amino ester) networks
Author(s) -
Safranski David L.,
Weiss Daiana,
Clark J. Brian,
Caspersen Birgitta S.,
Taylor W. Robert,
Gall Ken
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32983
Subject(s) - ethylene glycol , materials science , polymer , amine gas treating , polymer chemistry , chemical engineering , in vivo , modulus , molar mass , composite material , organic chemistry , chemistry , microbiology and biotechnology , engineering , biology
Poly(β‐amino ester) networks have shown promise as tissue scaffolds. The objective of this work was to examine the effect of changing poly(ethylene glycol) diacrylate concentration on poly(β‐amino ester) network properties and to assess the degradable polymers' in vivo response, using magnetic resonance imaging (MRI) and immunohistochemistry. The networks were synthesized from hexanediol diacrylate (HDDA), poly(ethylene glycol) diacrylate (PEGDA), and a primary amine, 3‐methoxypropylamine (3‐MOPA), with a fixed overall molar ratio of diacrylate to amine. Network properties were verified to insure that the networks possessed equivalent initial properties and structure other than chemistry. The effect of varying PEGDA concentration on water content, mass loss, and modulus was determined, where increasing the concentration of PEGDA increases both water content, mass loss rate, and decreases modulus. We also show that manipulating the network composition at ratios of 0:100, 10:90 and 25:75 (PEGDA:HDDA) does not elicit a major inflammatory response to subcutaneous implantation of the networks in mice. This work provides a foundation for tailoring poly(β‐amino ester) networks, based on degradation rate and modulus, as a means to tune the polymer properties for various biomedical applications. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.