Premium
Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants
Author(s) -
Scotchford C. A.,
Shataheri M.,
Chen P.S.,
Evans M.,
Parsons A. J.,
Aitchison G. A.,
Efeoglu C.,
Burke J. L.,
Vikram A.,
Fisher S. E.,
Rudd C. D.
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32977
Subject(s) - materials science , biocompatibility , composite number , biomedical engineering , bioactive glass , animal model , implant , dentistry , composite material , surgery , medicine , endocrinology , metallurgy
Abstract We report results from an initial small animal study designed to provide information on the biocompatibility of a novel biodegradable composite designed for craniomaxillofacial reconstruction. Rat calvarium was chosen as a clinically analogous model, which allowed comparison between experimental groups (PCL alone, PCL/phosphate glass, or PCL/bioglass implants) and control groups (empty defects or bone grafted defects). All animals recovered well from surgery and no clinical complications were observed. Histological assessment indicated a lack of inflammatory response. The amount of new bone formation at the dural aspect of the implant was statistically significantly higher in the PCL/phosphate glass group than the other experimental groups. This study confirms, in a clinically analogous model, the promise of the novel PCL/phosphate glass composite material. Work is planned toward manufacturing scale up and clinical trials. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2010.