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Wear behavior and in vitro cytotoxicity of wear debris generated from hydroxyapatite–carbon nanotube composite coating
Author(s) -
Lahiri Debrupa,
Benaduce Ana Paula,
Rouzaud Francois,
Solomon Jonathan,
Keshri Anup Kumar,
Kos Lidia,
Agarwal Arvind
Publication year - 2011
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32952
Subject(s) - materials science , biocompatibility , coating , composite material , carbon nanotube , composite number , toughness , tribology , fracture toughness , elastic modulus , metallurgy
This work evaluates the effect of carbon nanotube (CNT) addition to plasma‐sprayed hydroxyapatite (HA) coating on its tribological behavior, biocompatibility of the coating, and cytotoxicity of CNT‐containing wear debris. Biological response of the CNT‐containing wear debris is critical for osteoblasts, the bone‐forming cells, and macrophages, the cells that clear up wear debris from blood stream. The addition of 4 wt % CNTs to HA coating reduces the volume of wear debris generation by 80% because of the improved elastic modulus and fracture toughness. CNT reinforcement has a pronounced effect on the particle size in the wear debris and subsequent biological response. There was a slight increase in the numbers and viability of osteoblasts grown on HA–CNT compared with HA alone. The cytotoxic effect of HA and HA–CNT debris to macrophages and osteoblasts was similar, demonstrating that loose CNT does not pose a problem to these cells. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.