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Silicate, borosilicate, and borate bioactive glass scaffolds with controllable degradation rate for bone tissue engineering applications. I. Preparation and in vitro degradation
Author(s) -
Fu Qiang,
Rahaman Mohamed N.,
Fu Hailuo,
Liu Xin
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32824
Subject(s) - materials science , simulated body fluid , borosilicate glass , boron , bioactive glass , degradation (telecommunications) , porosity , chemical engineering , borate glass , silicate , composite material , biomedical engineering , chemistry , doping , organic chemistry , scanning electron microscope , telecommunications , optoelectronics , computer science , engineering , medicine
Bioactive glass scaffolds with a microstructure similar to that of dry human trabecular bone but with three different compositions were evaluated for potential applications in bone repair. The preparation of the scaffolds and the effect of the glass composition on the degradation and conversion of the scaffolds to a hydroxyapatite (HA)‐type material in a simulated body fluid (SBF) are reported here (Part I). The in vitro response of osteogenic cells to the scaffolds and the in vivo evaluation of the scaffolds in a rat subcutaneous implantation model are described in Part II. Scaffolds (porosity = 78–82%; pore size = 100–500 μm) were prepared using a polymer foam replication technique. The glasses consisted of a silicate (13‐93) composition, a borosilicate composition (designated 13‐93B1), and a borate composition (13‐93B3), in which one‐third or all of the SiO 2 content of 13‐93 was replaced by B 2 O 3 , respectively. The conversion rate of the scaffolds to HA in the SBF increased markedly with the B 2 O 3 content of the glass. Concurrently, the pH of the SBF also increased with the B 2 O 3 content of the scaffolds. The compressive strengths of the as‐prepared scaffolds (5–11 MPa) were in the upper range of values reported for trabecular bone, but they decreased markedly with immersion time in the SBF and with increasing B 2 O 3 content of the glass. The results show that scaffolds with a wide range of bioactivity and degradation rate can be achieved by replacing varying amounts of SiO 2 in silicate bioactive glass with B 2 O 3 . © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.