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Design and characterization of PEGylated terpolymer biomaterials
Author(s) -
Heath Daniel E.,
Cooper Stuart L.
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32811
Subject(s) - materials science , methacrylate , copolymer , polymer , ethylene glycol , polymer chemistry , protein adsorption , chemical engineering , absorption of water , contact angle , adsorption , composite material , organic chemistry , chemistry , engineering
A terpolymer copolymerized from hexyl methacrylate, methyl methacrylate, and poly(ethylene glycol) methacrylate (PEGMA) was synthesized. Polymers containing 0–25 mol % PEGMA were studied. As the mole fraction of PEGMA in the polymer chains increased, the material becomes more hydrophilic as observed by a decrease in the contact angle of water (81°–68°) and an increase in the equilibrium water absorption (0.7–237 wt %). Furthermore, the material shows nonfouling interfacial properties through resistance to protein adsorption and cellular attachment. A total of 1.2 μg/cm 2 fibrinogen, 18,000 HUVECs/cm 2 , and 3,000,000 platelets/cm 2 adsorbed or adhered on non‐PEGylated materials, whereas very low amounts of protein or cells were observed on materials containing ≥15 mol % PEGMA. Being thermoplastic, the polymer can be processed postsynthesis. To illustrate the processing capabilities of the material, polymer solutions were electrospun into nonwoven fibrous scaffold, which also retained their nonfouling character. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.