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Identification of osteoconductive and biodegradable polymers from a combinatorial polymer library
Author(s) -
Brey Darren M.,
Chung Cindy,
Hankenson Kurt D.,
Garino Jonathon P.,
Burdick Jason A.
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32769
Subject(s) - materials science , polymer , polymer science , identification (biology) , composite material , botany , biology
Abstract Combinatorial polymer syntheses are now being utilized to create libraries of materials with potential utility for a wide variety of biomedical applications. We recently developed a library of photopolymerizable and biodegradable poly(β‐amino ester)s (PBAEs) that possess a range of tunable properties. In this study, the PBAE library was assessed for candidate materials that met design criteria (e.g., physical properties such as degradation and mechanical strength and in vitro cell viability and osteoconductive behavior) for scaffolding in mineralized tissue repair. The most promising candidate, A6, was then processed into three‐dimensional porous scaffolds and implanted subcutaneously and only presented a mild inflammatory response. The scaffolds were then implanted intramuscularly and into a critical‐sized cranial defect either alone or loaded with bone morphogenetic protein‐2 (BMP‐2). The samples in both locations displayed mineralized tissue formation in the presence of BMP‐2, as evident through radiographs, micro‐computed tomography, and histology, whereas samples without BMP‐2 showed minimal or no mineralized tissue. These results illustrate a process to identify a candidate scaffolding material from a combinatorial polymer library, and specifically for the identification of an osteoconductive scaffold with osteoinductive properties via the inclusion of a growth factor. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010

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