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Osteoconductivity of modified fluorcanasite glass–ceramics for bone tissue augmentation and repair
Author(s) -
BandyopadhyayGhosh S.,
Faria P. E. P.,
Johnson A.,
Felipucci D. N. B.,
Reaney I. M.,
Salata L. A.,
Brook I. M.,
Hatton P. V.
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32750
Subject(s) - materials science , biocompatibility , ceramic , scanning electron microscope , bioactive glass , wax , glass ceramic , biomedical engineering , composite material , hard tissue , bone tissue , biomaterial , casting , dentistry , metallurgy , nanotechnology , medicine
Abstract Modified fluorcanasite glasses were fabricated by either altering the molar ratios of Na 2 O and CaO or by adding P 2 O 5 to the parent stoichiometric glass compositions. Glasses were converted to glass–ceramics by a controlled two‐stage heat treatment process. Rods (2 mm × 4 mm) were produced using the conventional lost‐wax casting technique. Osteoconductive 45S5 bioglass was used as a reference material. Biocompatibility and osteoconductivity were investigated by implantation into healing defects (2 mm) in the midshaft of rabbit femora. Tissue response was investigated using conventional histology and scanning electron microscopy. Histological and histomorphometric evaluation of specimens after 12 weeks implantation showed significantly more bone contact with the surface of 45S5 bioglass implants when compared with other test materials. When the bone contact for each material was compared between experimental time points, the Glass–Ceramic 2 (CaO rich) group showed significant difference ( p = 0.027) at 4 weeks, but no direct contact at 12 weeks. Histology and backscattered electron photomicrographs showed that modified fluorcanasite glass–ceramic implants had greater osteoconductivity than the parent stoichiometric composition. Of the new materials, fluorcanasite glass–ceramic implants modified by the addition of P 2 O 5 showed the greatest stimulation of new mineralized bone tissue formation adjacent to the implants after 4 and 12 weeks implantation. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010