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Fabrication and characterization of poly( D,L ‐lactide‐ co ‐glycolide)/hydroxyapatite nanocomposite scaffolds for bone tissue regeneration
Author(s) -
Aboudzadeh Neda,
Imani Mohammad,
Shokrgozar Mohammad Ali,
Khavandi Alireza,
Javadpour Jafar,
Shafieyan Yousef,
Farokhi Mehdi
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32673
Subject(s) - materials science , nanocomposite , regeneration (biology) , fabrication , characterization (materials science) , tissue engineering , biomedical engineering , chemical engineering , composite material , nanotechnology , medicine , engineering , pathology , biology , microbiology and biotechnology , alternative medicine
Conventional methods in fabrication of scaffolds based on polymer/bioceramic composites frequently make use of solution casting then particle leaching. The residues of common organic solvents can get trapped in this technique hence provide safety concerns on final scaffold. In this study, N ‐methyl pyrrolidone was used as an approved solvent for parenteral pharmaceutical products especially implants with acceptable toxicological profile. A combined freeze drying and solvent casting methods were adopted for complete removal of the solvent from final scaffold structure. Biodegradable scaffolds based on poly ( D,L ‐lactide‐co‐glycolide) and different percentages of nanohydroxyapatite (25, 35, and, 45% w/w) were characterized thoroughly regarding porosity, pore distribution as well as their bioactivity and biocompatibility. The results showed 70–80% porosity with a size distribution in the range of 50–200 μm for different conditions. Bioactivity of the scaffolds was directly dependent on the bioceramic content in the samples according to the results. Composites and neat samples showed the same cytocompatibility profile. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010