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Chronic inflammatory responses to microgel‐based implant coatings
Author(s) -
Bridges Amanda W.,
Whitmire Rachel E.,
Singh Neetu,
Templeman Kellie L.,
Babensee Julia E.,
Lyon L. Andrew,
García Andrés J.
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32669
Subject(s) - materials science , ethylene glycol , capsule , biomedical engineering , implant , histology , inflammation , chemical engineering , pathology , medicine , surgery , immunology , botany , engineering , biology
Inflammatory responses to implanted biomedical devices elicit a foreign body fibrotic reaction that limits device integration and performance in various biomedical applications. We examined chronic inflammatory responses to microgel conformal coatings consisting of thin films of poly( N ‐isopropylacrylamide) hydrogel microparticles cross‐linked with poly(ethylene glycol) diacrylate deposited on poly(ethylene terephthalate) (PET). Unmodified and microgel‐coated PET disks were implanted subcutaneously in rats for 4 weeks and explants were analyzed by histology and immunohistochemistry. Microgel coatings reduced chronic inflammation and resulted in a more mature/organized fibrous capsule. Microgel‐coated samples exhibited 22% thinner fibrous capsules that contained 40% fewer cells compared to unmodified PET disks. Furthermore, microgel‐coated samples contained significantly higher levels of macrophages (80%) than unmodified PET controls. These results demonstrate that microgel coatings reduce chronic inflammation to implanted biomaterials. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010