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Biomedical research of novel biodegradable copoly(amino acid)s based on 6‐aminocaproic acid and L ‐proline
Author(s) -
Zhang Weipeng,
Shao Jianmin
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32655
Subject(s) - cytotoxicity , hemolysis , apoptosis , materials science , proline , cell cycle , polymer , cell , in vitro , amino acid , viability assay , biochemistry , cell growth , biology , immunology , composite material
The biomedical properties of novel biodegradable copoly(amino acid)s based on 6‐aminocaproic acid and L ‐proline were analyzed in this article. The cytotoxicity of the copolymer films was tested in vitro using human embryonic kidney (HEK) 293 cells. The cell proliferation, cell cycle, cell apoptosis, and hemolysis of the polymers were also investigated. No significant cytotoxic response was detected statistically by cytotoxicity assay, and the results of cell apoptosis and cell cycle showed that there were no statistically significant differences in them. Generally, the cells spread and grew well on polymer film. Meanwhile, the extent of hemolysis on the polymers was acceptable. Evaluation of cytotoxicity by cell cycle and apoptosis as a supplementary assay is correspondingly discussed in this article. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010