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Influence of a magnesium‐fluoride coating of magnesium‐based implants (MgCa0.8) on degradation in a rabbit model
Author(s) -
Thomann Martina,
Krause Christian,
Angrisani Nina,
Bormann Dirk,
Hassel Thomas,
Windhagen Henning,
MeyerLindenberg Andrea
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32639
Subject(s) - materials science , magnesium , magnesium fluoride , degradation (telecommunications) , coating , rabbit (cipher) , fluoride , metallurgy , composite material , inorganic chemistry , electronic engineering , chemistry , statistics , mathematics , engineering
MgCa0.8 cylinders (2.5 × 25 mm 2 ) were coated with a magnesium‐fluoride layer and implanted in the marrow cavities of both tibiae of 10 New Zealand White rabbits. The implantation duration was 3 and 6 months. The implants were clinically well tolerated. Micro‐computed tomography revealed a new bone formation at the edges of the implants as well as an endosteal and periosteal remodeling. Using EDX‐analysis, a calcium and phosphorus rich degradation layer could be found on the implant surface. It was covered by an incomplete layer containing fluoride. The analysis by weight before implantation and after 3 and 6 months, respectively, showed a slight decrease in volume in comparison to uncoated implants. When compared with uncoated implants, the mechanical properties of the coated implants exhibited a reduction in strength after 3 months. After 6 months, the strength of the coated implants was higher than that of uncoated cylinders. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res 2010