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1 H‐NMR spectroscopic study of the effect of aging vascular prostheses made of poly(ethylene terephthalate) on the macromolecular weight
Author(s) -
Chaouch W.,
Dieval F.,
Le Nouen D.,
Defoin A.,
Chakfe N.,
Durand B.
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32599
Subject(s) - macromolecule , ethylene , materials science , polyethylene terephthalate , poly ethylene , titration , polymer chemistry , nuclear magnetic resonance spectroscopy , spectroscopy , polyester , proton nmr , polyethylene , organic chemistry , catalysis , composite material , chemistry , biochemistry , physics , quantum mechanics
Trichloroacetyl isocyanate reacts rapidly and quantitatively with both acid and hydroxyl chain ends to form derivatives that can be readily determined by 1 H‐NMR spectroscopy. This method provides a convenient mean for characterization of polyethylene terephthalate (PET) end‐groups. The 1 H‐NMR spectroscopy has been applied to describe the chemical aging of the PET vascular prostheses by determination of the hydroxyl and carboxyl end‐group concentrations and therefore the macromolecular weight. To validate 1 H‐NMR results, we used chemical titration of the end‐groups and classical viscosimetric method as complementary techniques. The analyses made on the explants of different lifetime demonstrated a significant deterioration compared with the virgin prostheses. A high degradation of macromolecular weight is observed. This phenomenon is explained by a random scission of the ester linkages. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2009