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Effects of alendronate on bone formation and osteoclastic resorption after implantation of beta‐tricalcium phosphate
Author(s) -
Tanaka Takaaki,
Saito Mitsuru,
Chazono Masaaki,
Kumagae Yoshio,
Kikuchi Takahiro,
Kitasato Seiichiro,
Marumo Keishi
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32560
Subject(s) - bone resorption , materials science , osteoclast , resorption , acid phosphatase , bone formation , phosphate , bone remodeling , medicine , chemistry , biochemistry , enzyme , receptor
The aim of this study was to determine the effects of alendronate (ALN) on osteoclastic resorption of β‐tricalcium phosphate (β‐TCP) and bone formation. β‐TCP blocks of 75% porosity, with or without ALN treatment, were implanted into cavities drilled in rabbit femoral condyles. New bone formation, residual amount of β‐TCP, and the number of tartrate‐resistant acid phosphatase‐positive cells were evaluated 2 weeks after surgery. The results show that local application of ALN at a concentration of 10 −2 to 10 −6 M reduced the number of osteoclasts on the surface of β‐TCP. New bone formation was also inhibited by ALN in a dose‐dependent manner. Thus, inhibition of osteoclast formation resulted in reduced β‐TCP resorption and bone formation. These results suggest that osteoclast‐mediated resorption plays an important role in bone formation and a coupling‐like phenomenon could occur in β‐TCP‐filled bone defects. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2010