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Characterization of dextrin‐based hydrogels: Rheology, biocompatibility, and degradation
Author(s) -
Carvalho Joana,
Moreira Susana,
Maia João,
Gama Francisco M.
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32553
Subject(s) - dextrin , biocompatibility , self healing hydrogels , materials science , methacrylate , polymer chemistry , hydrolysis , biomaterial , chemical engineering , biomedical engineering , copolymer , polymer , chemistry , organic chemistry , composite material , nanotechnology , medicine , starch , engineering , metallurgy
A new class of degradable dextrin‐based hydrogels (dextrin‐HEMA) was developed. The hydroxyethyl methacrylate ester (HEMA) hydroxyl groups were activated with N , N ′‐carbonyldiimidazole (CDI), followed by their coupling to dextrin, yielding a derivatized material that can be polymerized in aqueous solution to form hydrogels. A comparative study of the stability of the dextrin‐HEMA hydrogels and dextrin‐vinyl acrylate (dextrin‐VA, produced in previous work) revealed that only the firsts are effectively hydrolyzed under physiological conditions. A severe mass loss of dextrin‐HEMA gels occurs over time, culminating in the complete dissolution of the gels. Rheologic analysis confirmed that physical structuring is less pronounced when dextrin is modified with methacrylate side groups. The biocompatibility results revealed that the dextrin hydrogels have negligible cell toxicity, irrespective of the hydrogel type (HEMA and VA), allowing cell adhesion and proliferation. Gathering the biocompatibility and the ability to tailor the release profiles, we consider dextrin a promising biomaterial for biomedical applications, namely for controlled release. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2010