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Titanium dioxide nanotubes enhance bone bonding in vivo
Author(s) -
Bjursten Lars M.,
Rasmusson Lars,
Oh Seunghan,
Smith Garrett C.,
Brammer Karla S.,
Jin Sungho
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32463
Subject(s) - nanotopography , materials science , osseointegration , titanium , implant , titanium dioxide , in vivo , nanotube , osteoblast , adhesion , biomedical engineering , nanotechnology , composite material , in vitro , carbon nanotube , metallurgy , chemistry , surgery , medicine , biochemistry , microbiology and biotechnology , biology
Implant topography is critical to the clinical success of bone‐anchored implants, yet little is known how nano‐modified implant topography affects osseointegration. We investigate the in vivo bone bonding of two titanium implant surfaces: titanium dioxide (TiO 2 ) nanotubes and TiO 2 gritblasted surfaces. In previous in vitro studies, the topography of the TiO 2 nanotubes improved osteoblast proliferation and adhesion compared with gritblasted titanium surfaces. After four weeks of implantation in rabbit tibias, pull‐out testing indicated that TiO 2 nanotubes significantly improved bone bonding strength by as much as nine‐fold compared with TiO 2 gritblasted surfaces. Histological analysis confirmed greater bone‐implant contact area, new bone formation, and calcium and phosphorus levels on the nanotube surfaces. It is anticipated that further studies will contribute to a better understanding of the effect of implant nanotopography on in vivo bone formation and bonding strength. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010