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Silicate–apatite composite layers on external fixation rods and in vitro evaluation using fibroblast and osteoblast
Author(s) -
Wang Xiupeng,
Ito Atsuo,
Sogo Yu,
Li Xia,
Oyane Ayako
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32436
Subject(s) - materials science , apatite , simulated body fluid , composite number , titanium , supersaturation , calcium , calcium silicate , rod , phosphate , chemical engineering , silicate , nuclear chemistry , composite material , metallurgy , biochemistry , chemistry , organic chemistry , medicine , alternative medicine , pathology , engineering
Abstract A silicate–apatite layer was formed on commercially available anodically oxidized titanium rods using Na 2 SiO 3 ‐containing supersaturated calcium phosphate solutions. With the increase in the concentration of Na 2 SiO 3 in the supersaturated calcium phosphate solutions, the amounts of silicon that precipitated on the titanium rods increased from 0 to 0.07 ± 0.02 μg/cm 2 ; meanwhile, the amounts of calcium and phosphorus that precipitated on the titanium rods decreased from 11.6 ± 1.6 and 5.7 ± 2.0 μg/cm 2 to 2.6 ± 0.5 and 3.0 ± 1.0 μg/cm 2 , respectively. The present silicate–apatite composite layers, which demonstrated increased fibroblastic proliferation and osteoblastic proliferation and differentiation in vitro , are promising as coating layers on external fixation pins for decreasing the pin tract infection rate in vivo . © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010