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Functionally graded β‐TCP/PCL nanocomposite scaffolds: In vitro evaluation with human fetal osteoblast cells for bone tissue engineering
Author(s) -
Ozkan Seher,
Kalyon Dilhan M.,
Yu Xiaojun
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32425
Subject(s) - materials science , polycaprolactone , tissue engineering , biomedical engineering , osteoblast , nanocomposite , composite material , nanotechnology , in vitro , polymer , medicine , biochemistry , chemistry
Abstract The engineering of biomimetic tissue relies on the ability to develop biodegradable scaffolds with functionally graded physical and chemical properties. In this study, a twin‐screw‐extrusion/spiral winding (TSESW) process was developed to enable the radial grading of porous scaffolds (discrete and continuous gradations) that were composed of polycaprolactone (PCL), β‐tricalciumphosphate (β‐TCP) nanoparticles, and salt porogens. Scaffolds with interconnected porosity, exhibiting myriad radial porosity, pore‐size distributions, and β‐TCP nanoparticle concentration could be obtained. The results of the characterization of their compressive properties and in vitro cell proliferation studies using human fetal osteoblast cells suggest the promising nature of such scaffolds. The significant degree of freedom offered by the TSESW process should be an additional enabler in the quest toward the mimicry of the complex elegance of the native tissues. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010