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Rheological blends for drug delivery. I. Characterization in vitro
Author(s) -
Hoare Todd,
Zurakowski David,
Langer Robert,
Kohane Daniel S.
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32392
Subject(s) - materials science , rheology , polymer , viscoelasticity , shear thinning , drug delivery , chemical engineering , biocompatibility , polymer blend , kinetics , biodegradable polymer , composite material , nanotechnology , copolymer , physics , quantum mechanics , engineering , metallurgy
Rheological blends of hyaluronic acid (HA) and hydroxypropylmethyl cellulose (HPMC) are attractive as injectable drug delivery vehicles given their shear thinning viscoelastic rheological properties and excellent biocompatibility. In this study, the rheological and water binding properties of HA‐HPMC blends are investigated to optimize both the injectability and the drug release kinetics of polymer blends. The time required to release 75% of a bupivacaine payload was correlated with the overall polymer concentration of the blend and the water binding properties of the constituent polymers. This correlation enables the tuning of drug release kinetics over a range of several hours according to the total concentration and ratio of the polymers used in the blend. The injectability is also promoted by polymer blending; HPMC suppresses the high yield stress of HA solutions, whereas HA induces flow instabilities in the needle, which facilitate blend injection via plug flow. Consequently, significantly higher polymer concentrations can be injected as blends compared with that achievable with either of the polymers alone, extending the potential of these polymers for drug delivery. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010