Premium
A new route to produce starch‐based fiber mesh scaffolds by wet spinning and subsequent surface modification as a way to improve cell attachment and proliferation
Author(s) -
Tuzlakoglu K.,
Pashkuleva I.,
Rodrigues M. T.,
Gomes M. E.,
van Lenthe G. H.,
Müller R.,
Reis R. L.
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32358
Subject(s) - materials science , spinning , surface modification , composite material , fiber , nanotechnology , chemical engineering , engineering
This study proposes a new route for producing fiber mesh scaffolds from a starch–polycaprolactone (SPCL) blend. It was demonstrated that the scaffolds with 77% porosity could be obtained by a simple wet‐spinning technique based on solution/precipitation of a polymeric blend. To enhance the cell attachment and proliferation, Ar plasma treatment was applied to the scaffolds. It was observed that the surface morphology and chemical composition were significantly changed because of the etching and functionalization of the fiber surfaces. XPS analyses showed an increase of the oxygen content of the fiber surfaces after plasma treatment (untreated scaffolds O/C:0.32 and plasma‐treated scaffolds O/C:0.41). Both untreated and treated scaffolds were examined using a SaOs‐2 human osteoblast‐like cell line during 2 weeks of culture. The cell seeded on wet‐spun SPCL fiber mesh scaffolds showed high viability and alkaline phosphatase enzyme activity, with those values being even higher for the cells seeded on the plasma‐treated scaffolds. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010