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Degradation studies on biodegradable nanocomposite based on polycaprolactone/polycarbonate (80:20%) polyhedral oligomeric silsesquioxane
Author(s) -
Raghunath Joanne,
Georgiou George,
Armitage David,
Nazhat Showan N.,
Sales Kevin M.,
Butler Peter E.,
Seifalian Alexander M.
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32335
Subject(s) - silsesquioxane , materials science , polycaprolactone , nanocomposite , polymer , polycarbonate , chemical engineering , biodegradation , dynamic mechanical analysis , contact angle , tissue engineering , biodegradable polymer , composite material , polymer chemistry , biomedical engineering , organic chemistry , chemistry , medicine , engineering
The development of biocompatible polymers has greatly advanced the field of tissue engineering. Some tissues can be propagated on a nondegradable scaffold. Tissue such as cartilage, however, is a complex tissue in which the chondrocytes require their own synthesized extracellular matrix (ECM) to function. Suitable scaffolds for tissue engineering cartilage should provide mechanical strength and degrade at a similar rate to that of cell growth and ECM production. We have developed a biodegradable nanocomposite based on polycaprolactone and polycarbonate polyurethane (PCU) with an incorporated polyhedral oligomeric silsesquioxane (POSS) (POSS modified Poly(caprolactone/carbonate) urethane/urea). Previous work on POSS incorporated into PCU (POSS‐PCU) has been shown to possess good mechanical strength, elasticity and resistance to degradation. This series of experiments involved exposing this polymer to a selection of accelerated degradative solutions for up to 8 weeks. The samples were analyzed by infra‐red spectroscopy, scanning electron microscopy, X‐ray microanalysis, contact angle analysis, and stress‐strain mechanical analysis. Degradation of hard and soft segments of the nanocomposite was evident by infra‐red spectroscopy in all conditioned samples. POSS nanocage degradation was evident in some oxidative/peroxidative systems accompanied by gross changes in surface topography and significant changes in mechanical properties. The hydrophobic polymer became more hydrophilic in all conditions. This biodegradable nanocomposite demonstrated steady degradation with protection of mechanical properties when exposed to hydrolytic enzymes and plasma protein fractions and exhibited more dramatic degradation by oxidation.This pattern may be potentially employed in tissue engineering scaffolds where controlled degradation and retained structural stability of the scaffold is required. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009