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Biomimetic, bioactive etheric polyphosphazene‐poly(lactide‐ co ‐glycolide) blends for bone tissue engineering
Author(s) -
Deng Meng,
Nair Lakshmi S.,
Nukavarapu Syam P.,
Kumbar Sangamesh G.,
Brown Justin L.,
Krogman Nicholas R.,
Weikel Arlin L.,
Allcock Harry R.,
Laurencin Cato T.
Publication year - 2010
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32334
Subject(s) - materials science , polyphosphazene , apatite , ultimate tensile strength , composite material , polymer , chemical engineering , phosphazene , biomedical engineering , engineering , medicine
The long‐term goal of this work is to develop biomimetic polymer‐based systems for bone regeneration that both allow for neutral pH degradation products and have the ability to nucleate bonelike apatite. In this study, the etheric biodegradable polyphosphazene, poly[(50%ethyl glycinato)(50%methoxyethoxyethoxy)phosphazene] (PNEG 50 MEEP 50 ) was blended with poly(lactide‐ co ‐glycolide) PLAGA and studied their ability to produce high‐strength degradable biomaterials with bioactivity. Accordingly, two blends with weight ratios of PNEG 50 MEEP 50 to PLAGA 25:75 (BLEND25) and 50:50 (BLEND50) were fabricated using a mutual solvent approach. Increases in PNEG 50 MEEP 50 content in the blend system resulted in decreased elastic modulus of 779 MPa when compared with 1684 MPa (PLAGA) as well as tensile strength 7.9 MPa when compared with 25.7 MPa (PLAGA). However, the higher PNEG 50 MEEP 50 content in the blend system resulted in higher Ca/P atomic ratio of the apatite layer 1.35 (BLEND50) when compared with 0.69 (BLEND25) indicating improved biomimicry. Furthermore, these blends supported primary rat osteoblast adhesion and proliferation with an enhanced phenotypic expression when compared with PLAGA. These findings establish the suitability of PNEG 50 MEEP 50 ‐PLAGA biodegradable blends as promising bioactive materials for orthopedic applications. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010