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Surface engineering of poly( D , L ‐lactic acid) by entrapment of soluble eggshell membrane protein
Author(s) -
Lu JianWei,
Li Qiang,
Qi QingLei,
Guo ZhaoXia,
Yu Jian
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32304
Subject(s) - eggshell membrane , materials science , membrane , attenuated total reflection , fourier transform infrared spectroscopy , contact angle , tissue engineering , lactic acid , chemical engineering , biomedical engineering , composite material , chemistry , biochemistry , bacteria , biology , medicine , engineering , genetics
Soluble eggshell membrane protein (SEP) is used to engineer poly( D , L ‐lactic acid) (PDL‐LA) membrane surface by a physical entrapment method to enhance cytocompatibility. Attenuated total reflection Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy, and contact angle measurements are used to characterize SEP‐modified PDL‐LA membrane surface and confirm the formation of an even and stable layer of SEP on PDL‐LA membrane surface. NIH3T3 cell lines are used as model cells to evaluate cytocompatibility of the SEP‐modified PDL‐LA membrane, which is much better than that of virgin PDL‐LA membrane. The enhanced cytocompatibility facilitates potential application in tissue engineering. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009