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Spreading of an anchorage‐dependent cell on a selectively ligand‐coated substrate mediated by receptor‐ligand binding
Author(s) -
Liu Ping,
Zhang Yong W.,
Yu Hanry,
Zhang Xin,
Cheng Qian H.,
Lu Chun,
Bonfield William
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32258
Subject(s) - materials science , adhesion , biophysics , ligand (biochemistry) , cell adhesion , receptor , substrate (aquarium) , composite material , chemistry , biology , biochemistry , ecology
Abstract A continuum model was proposed to simulate a biological cell adhering to a substrate surface domain with selectively coated ligands. Cell adhesion was modeled by a traction‐separation law depending on the receptor‐ligand distance and their densities. It was found that the obtained spreading patterns are consistent with published experimental data and that adhesion requires a nonuniform distribution of receptors at the spreading front with convex fronts requiring a much higher receptor density than concave fronts. Adhesion strength was also found to be more influential than adhesion energy on the spreading kinetics. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009