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A novel biocompatible adhesive incorporating plant‐derived monomers
Author(s) -
Klapperich Catherine M.,
Noack Cassandra L.,
Kaufman Jessica D.,
Zhu Lin,
Bonnaillie Laetitia,
Wool Richard P.
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32250
Subject(s) - materials science , adhesive , copolymer , transdermal , methacrylate , ethylene glycol dimethacrylate , monomer , ethylene glycol , polymer , methyl methacrylate , tissue engineering , biocompatible material , polymer chemistry , chemical engineering , biomedical engineering , nanotechnology , composite material , medicine , methacrylic acid , layer (electronics) , pharmacology , engineering
We describe a new class of biomaterials with potential for a variety of applications in tissue engineering, wound healing, and transdermal drug delivery. These materials are based on oleic methyl ester (OME), which is derived from various plant oils including soybean oil. The OME was acrylated (AOME) and subsequently copolymerized with methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA) to form pressure sensitive adhesives (PSAs). We assessed the cytocompatibility of each PSA product using Alamar Blue and Live/Dead assays. It was found that after 2 h, human fibroblast cells attached on all four of the PSA polymers tested. After 24 h, cell spreading was seen on all materials with the exception of the polymerized AOME product (PAOME). Cells attached to the copolymer PSA products continued to proliferate for up to 2 weeks, as shown by fluorescent confocal microscopy imaging. Finally, a mechanical analysis of each of the copolymers is presented demonstrating that they have a range of mechanical properties and cell adhesiveness depending on the formulation, making them attractive candidates for use as bioactive adhesives. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009