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Effect of ring‐opening polymerization condition on the characteristic and mechanical properties of hydroxyapatite/poly(ethylene glutarate) biomaterials
Author(s) -
Monvisade Pathavuth,
Siriphan Punnama,
Tapcharoen Walailak
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32133
Subject(s) - materials science , simulated body fluid , polymerization , peg ratio , porosity , compressive strength , composite material , molar mass distribution , composite number , ethylene , ethylene glycol , polymer chemistry , chemical engineering , polymer , organic chemistry , chemistry , catalysis , scanning electron microscope , finance , engineering , economics
Preparation of hydroxyapatite/poly(ethylene glutarate) (HAp/PEG) composites was carried out by ring‐opening polymerization (ROP) of cyclic oligo(ethylene glutarate) in porous HAp scaffolds using various reaction temperatures and times. The content of ROP‐PEG interpenetrated into the porous HAp scaffold was about 13–18 wt % with the values of number average molecular weight ( $ \overline {M_{\rm n} } $ ) and weight average molecular weight ( $ \overline {M_{\rm W} } $ ) of 2120–3630 and 2760–5250 g/mol, respectively. The increase in polymerization time and temperature brought about increase in molecular weight of ROP‐PEG, but decrease in its content. Compressive strength and compressive modulus of the HAp/PEG composites were about 5.8–20.1 and 105–208 MPa, respectively. These mechanical properties depend upon the effects of distribution, content, and molecular weight of ROP‐PEG in the composites. In vitro bioactivity of the HAp/PEG composites was studied by soaking them in simulated body fluid (SBF) for 28 days. The formation of HAp nanocrystal on the composite surfaces through the consumption of calcium and phosphorus from the SBF solution was observed after soaking, indicating the bioactivity of these HAp/PEG composites. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009