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Aspects of the in vitro bioactivity of hydraulic calcium (alumino)silicate cement
Author(s) -
Coleman Nichola J.,
Awosanya Kunle,
Nicholson John W.
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32070
Subject(s) - materials science , calcium silicate hydrate , simulated body fluid , dissolution , cement , calcium silicate , silicate , apatite , portland cement , calcium hydroxide , chemical engineering , calcium , tobermorite , mineralogy , nucleation , composite material , metallurgy , geology , chemistry , organic chemistry , engineering
In response to a burgeoning interest in the prospective clinical applications of hydraulic calcium (alumino)silicate cements, the in vitro bioactivity and dissolution characteristics of a white Portland cement have been investigated. The formation of an apatite layer within 6 h of contact with simulated body fluid was attributed to the rapid dissolution of calcium hydroxide from the cement matrix and to the abundance of pre‐existing SiOH nucleation sites presented by the calcium silicate hydrate phase. A simple kinetic model has been used to describe the rate of apatite formation and an apparent pseudo‐second‐order rate constant for the removal of HPO 4 2− ions from solution has been calculated (k 2 = 5.8 ×10 −4 g mg −1 min −1 ). Aspects of the chemistry of hydraulic cements are also discussed with respect to their potential use in the remedial treatment of living tissue. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009