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Covalent surface modification of titanium oxide with different adhesive peptides: Surface characterization and osteoblast‐like cell adhesion
Author(s) -
Dettin Monica,
Bagno Andrea,
Gambaretto Roberta,
Iucci Giovanna,
Conconi Maria Teresa,
Tuccitto Nunzio,
Menti Anna Michela,
Grandi Claudio,
Di Bello Carlo,
Licciardello Antonino,
Polzonetti Giovanni
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32064
Subject(s) - materials science , adhesion , titanium , cell adhesion , surface modification , x ray photoelectron spectroscopy , surface roughness , osteoblast , adhesive , titanium alloy , nanotechnology , biomedical engineering , covalent bond , titanium oxide , surface finish , chemical engineering , alloy , composite material , metallurgy , organic chemistry , chemistry , biochemistry , in vitro , layer (electronics) , medicine , engineering
A fundamental goal in the field of implantology is the design of innovative devices suitable for promoting implant‐to‐tissue integration. This result can be achieved by means of surface modifications aimed at optimizing tissue regeneration. In the framework of oral and orthopedic implantology, surface modifications concern both the optimization of titanium/titanium alloy surface roughness and the attachment of biochemical factors able to guide cellular adhesion and/or growth. This article focuses on the covalent attachment of two different adhesive peptides to rough titanium disks. The capability of biomimetic surfaces to increase osteoblast adhesion and the specificity of their biological activity due to the presence of cell adhesion signal‐motif have also been investigated. In addition, surface analyses by profilometry, X‐ray photoelectron spectroscopy, and time of flight‐secondary ion mass spectrometry have been carried out to investigate the effects and modifications induced by grafting procedures. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009