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In vivo evaluation of bone‐bonding ability of RGD‐coated porous implant using layer‐by‐layer electrostatic self‐assembly
Author(s) -
Yang GuoLi,
He FuMing,
Yang XiaoFeng,
Wang XiaoXiang,
Zhao ShiFang
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32055
Subject(s) - osseointegration , materials science , implant , biomedical engineering , tibia , coating , layer (electronics) , dentistry , composite material , anatomy , medicine , surgery
RGD has been demonstrated to improve implant osseointegration. However, few studies are known about an effect of RGD coating on a bone‐bonding ability of screw‐shaped porous implant. The aim of this study was to investigate the effect of RGD coating using the layer‐by‐layer self‐assembly technique on the bone‐bonding ability of porous implant. 60 implants of 10 mm in length (30 control and 30 RGD‐coated) were inserted into femurs of 30 rabbits and 30 implants of 8 mm in length (15 control and 15 RGD‐coated) were inserted into tibias of 15 rabbits. At 4, 8, and 12 weeks post‐implantation, femurs and tibias were retrieved and prepared for removal torque tests (RTQ) and histomorphometric evaluation, respectively. No differences were found in the RTQ values between two implants at 4 weeks ( p = 0.932). There were statistical significances in the RTQ values at 8 and 12 weeks ( p = 0.002, 0.001, respectively). New bone was formed on both implant surfaces. The bone–implant contact pattern appeared to produce a broad‐based direct contact in both implants. The RGD‐coated implants showed a significantly greater BIC in the threads inside the cortical bone compared with the control implants at 4, 8, and 12 weeks ( p = 0.024, 0.041, 0.022, respectively). No differences were found in the bone area within the same threads between two implants at 4 weeks ( p = 0.806) whereas differences were found at 8 and 12 weeks ( p = 0.009, 0.031, respectively). It was concluded that RGD coating using the layer‐by‐layer self‐assembly technique has a positive effect on the bone‐bonding ability of porous implant. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009