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Chitosan‐based rechargeable long‐term antimicrobial and biofilm‐controlling systems
Author(s) -
Cao Zhengbing,
Sun Yuyu
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.32040
Subject(s) - biofilm , staphylococcus epidermidis , antimicrobial , chitosan , materials science , antibiotics , microbiology and biotechnology , staphylococcus aureus , antimicrobial drug , bacteria , chemistry , biology , organic chemistry , genetics
Chitosan, a natural cationic polymer, strongly binds anionic antibiotics (e.g., rifampin) through the formation of ionic complexes. The new system shows sustained rifampin release, leading to potent antimicrobial and biofilm‐controlling functions against gram‐positive bacteria including Staphylococcus epidermidis and Staphylococcus aureus , which are responsible for a wide range of medical device‐related infections, for longer than 30 days. Moreover, the released drugs can be recharged to further extend antimicrobial durations. Drug release mechanisms and potential applications of the new system are also discussed. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009