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Comparative in vivo evaluation of porous and dense duplex titanium and hydroxyapatite coating with high roughnesses in different implantation environments
Author(s) -
Borsari V.,
Fini M.,
Giavaresi G.,
Tschon M.,
Chiesa R.,
Chiusoli L.,
Salito A.,
Rimondini L.,
Giardino R.
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31995
Subject(s) - materials science , cortical bone , titanium , trabecular bone , surface roughness , osseointegration , biomedical engineering , porosity , osteoporosis , composite material , implant , anatomy , metallurgy , medicine , surgery
Ti (PG60) and Ti plus HA (HPG60) dense coatings with ultrahigh roughness (Ra: 74 ± 8 μm and 53 ± 18 μm, respectively) were compared to high Ti (Ti60) and Ti plus HA (HT60) high roughened porous coatings (Ra: 40 ± 7 μm and 36 ± 3 μm, respectively). Surfaces were implanted in cortical and trabecular bone of young adult (YOUNG), aged (AGED) and estrogen‐deficient sheep (OVX) and analyzed by means of histology, histomorphometry and push‐out tests 3 months after implantation. A significantly lower value in affinity index (AI) of PG60 when compared to TI60 ( p < 0.01) was observed in cortical bone. In trabecular bone, lower values in AI were found in TI60 and PG60 when compared to their HA‐coated surfaces ( p < 0.0005). Bone ingrowth (BI) of TI60 and PG60 was significantly lower than that of the HA‐coated surfaces in trabecular bone ( p < 0.05). Significantly lower values in BI in OVX sheep in comparison to YOUNG sheep in both cortical and trabecular bone were observed ( p < 0.05). Data showed that high roughness and Ti and HA‐coated surfaces are suitable for aged and osteoporotic patients. HA coatings represent the most successful strategy in trabecular bone. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009