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A new generation of high flex life polyurethane urea for polymer heart valve—Studies on in vivo biocompatibility and biodurability
Author(s) -
Thomas Vinoy,
Jayabalan Muthu
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31937
Subject(s) - biocompatibility , materials science , polyurethane , biomedical engineering , heart valve , in vivo , composite material , polymer , urea , fabrication , elastic modulus , flex , polyvinyl alcohol , surgery , medicine , metallurgy , organic chemistry , computer science , telecommunications , chemistry , microbiology and biotechnology , biology , alternative medicine , pathology
Development of new generation high flex life polyurethane urea (HFL18‐PU) with appropriate elastic modulus, biocompatibility, blood compatibility, resistant to calcification, and biodurability for the long‐term use as cardiac device is still a challenge. This study reports the development of a fully aliphatic, ether‐free physically cross‐linked and low elastic modulus (6.841 ± 0.27 MPa) polyurethane urea having in vivo biostability, in vivo biocompatibility and high flex‐life (721 ± 30 million cycles) that can satisfy the requirements for the fabrication of tri‐leaflet heart valve. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009