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The bone‐derived collagen containing mineralized matrix for the loading of collagen‐binding bone morphogenetic protein‐2
Author(s) -
Zhao Yannan,
Chen Bing,
Lin Hang,
Sun Wenjie,
Zhao Wenxue,
Zhang Jing,
Dai Jianwu
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31928
Subject(s) - materials science , bone morphogenetic protein , bone healing , bone morphogenetic protein 7 , matrix (chemical analysis) , bone morphogenetic protein 2 , biomedical engineering , microbiology and biotechnology , biophysics , anatomy , biochemistry , chemistry , in vitro , biology , medicine , composite material , gene
Bone tissue‐derived biomaterials have often been applied for bone repair because of their similarity to human bone in structure and composition. When combined with growth factors, they could accelerate bone formation. Here, we explore a collagen containing mineralized bone‐derived matrix (CCMBM) from bovine bone tissues, which not only maintains proper mechanical strength but also binds to the collagen‐binding recombinant human collagen‐binding bone morphogenetic protein‐2 (CBD‐BMP 2 ). By analyzing its morphology and composition, we found that CCMBM was porous and mainly composed of calcium compounds. CCMBM could provide mechanical support for bone injury repair. It also showed good biocompatibility and proper degradation rate that would be helpful for bone regeneration. In addition, the intentionally preserved collagen allowed the specific binding of CBD‐BMP 2 to CCMBM, and resulted in significantly increased osteogenesis in vivo . The results indicated that the combination of CCMBM with collagen‐binding BMP 2 could be emerged into an effective medical device for bone repair. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009