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Electrosynthesis of hydrogel films on metal substrates for the development of coatings with tunable drug delivery performances
Author(s) -
De Giglio E.,
Cometa S.,
Satriano C.,
Sabbatini L.,
Zambonin P. G.
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31908
Subject(s) - materials science , self healing hydrogels , methacrylate , ethylene glycol , chemical engineering , quartz crystal microbalance , drug delivery , photopolymer , polymer , swelling , polymer chemistry , polymerization , nanotechnology , adsorption , composite material , organic chemistry , chemistry , engineering
Novel polyacrylates‐based hydrogel thin films were prepared by electrochemical polymerization, a new method to obtain hydrogels directly onto metal substrates. 2‐Hydroxy‐ethyl‐methacrylate (HEMA), a macromer poly (ethylene‐glycol diacrylate) (PEGDA) and PEGDA copolymerized with acrylic acid (AA) were used to obtain hydrogels. The electrosynthesized coatings were characterized by X‐ray photoelectron spectroscopy, to assess their surface chemical composition, and by water content determination measurements, to characterize the swelling behavior. In particular, quartz crystal microbalance with dissipation monitoring was used to evaluate the pH‐dependency of the swelling for AA‐containing hydrogels. Moreover, a model protein (bovine serum albumin) and a model drug (caffeine) were entrapped within the hydrogel coatings during electrosynthesis, to examine the release performances and mechanisms of the electrosynthesized hydrogels. It was observed that all the examined polymers showed significant release properties and, in particular, AA‐containing hydrogel films confirmed a strong pH‐dependence as expected. These coatings seem to be promising in orthopedic field for in situ drug delivery applications. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009