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New class of anti‐microbial agents: Synthesis, characterization, and anti‐microbial activities of metal chelated polyurea
Author(s) -
Ahamad Tansir,
Kumar Vikrant,
Nishat Nahid
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31872
Subject(s) - polyurea , chelation , materials science , thermal stability , antibacterial activity , metal , nuclear chemistry , polymer , bacterial growth , schiff base , bacteria , polymer chemistry , organic chemistry , chemistry , composite material , polyurethane , metallurgy , biology , genetics
A new class of metal chelated polyurea have been synthesized by the reaction of toluene 2,4‐diisocyanate (TDI) with chelated Schiff base diamines. The synthesized polyurea have been characterized by analytical, spectral, and thermal analysis. The results of TGA ascribed that [Cu(II)‐PoU A ] show better heat resistant properties than other metals chelated polyurea. The antibacterial activities of all the synthesized polymers were determined using the shaking flask method, where 30 mg/mL concentrations of each compound were tested against 10 5 CFU/mL solutions of S. aureus, E. coli, B. subtillis, S. typhi . The number of viable bacteria was calculated by using the spread plate method on agar plates and the number of viable bacteria was counted after 24 h of incubation period at 37°C. All the polymers showed good antibacterial activity. The Cu(II) chelated polyurea show higher zone of inhibition then other due to higher stability constant and may be used in biomedical applications. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res 2009