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Preparation and in vitro characterization of novel bioactive glass ceramic nanoparticles
Author(s) -
Hong Zhongkui,
Reis Rui L.,
Mano João F.
Publication year - 2009
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31848
Subject(s) - materials science , simulated body fluid , nanoparticle , bioactive glass , ceramic , chemical engineering , pulmonary surfactant , polyethylene glycol , composite material , nuclear chemistry , nanotechnology , scanning electron microscope , engineering , chemistry
SiO 2 ‐CaO‐P 2 O 5 ternary bioactive glass ceramic (BGC) nanoparticles with different compositions were prepared via a three‐step sol‐gel method. Polyethylene glycol was selected to be used as the surfactant to improve the dispersion of the nanoparticles. The morphology and composition of these BGC nanoparticles were observed by ESEM and EDX. All the BGC particles obtained in this method were about 20 nm in diameter. XRD analysis demonstrated that the different compositions can result in very different crystallinities for the BGC nanoparticles. Bioactivity tests in simulated body fluid solution (SBF), and degradability in phosphate buffer solution (PBS), were performed in vitro . SEM, EDX, and XRD were employed to monitor the surface variation of neat poly( L ‐lactic acid), PLLA, foam and PLLA/BGC porous scaffolds during incubation. The BGC nanoparticles with lower phosphorous and relative higher silicon content exhibited enhanced mineralization capability in SBF and a higher solubility in PBS medium. Such novel nanoparticles may have potential to be used in different biomedical applications, including tissue engineering or the orthopedic field. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res 2009