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Polyurethane scaffold formation via a combination of salt leaching and thermally induced phase separation
Author(s) -
Heijkants R. G. J. C.,
van Calck R. V.,
van Tienen T. G.,
de Groot J. H.,
Pennings A. J.,
Buma P.,
Veth R. P. H.,
Schouten A. J.
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31829
Subject(s) - interconnectivity , materials science , porosity , polyurethane , leaching (pedology) , composite material , scaffold , chemical engineering , polymer , porous medium , biomedical engineering , medicine , environmental science , artificial intelligence , computer science , soil science , soil water , engineering
Abstract Porous scaffolds have been made from twopolyurethanes based on thermally induced phase separation of polymer dissolved in a DMSO/water mixture in combination with salt leaching. It is possible to obtain very porous foams with a very high interconnectivity. A major advantage of this method is that variables like porosity, pore size, and interconnectivity can be independently adjusted with the absence of toxic materials in the production process. The obtained compression moduli were between 200 kPa and 1 MPa with a variation in porosity between 76 and 84%. Currently the biological and medical aspects are under evaluation. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008