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Scaffolds based on hyaluronan crosslinked with a polyaminoacid: Novel candidates for tissue engineering application
Author(s) -
Pitarresi G.,
Palumbo F. S.,
Cavallaro G.,
Faré S.,
Giammona G.
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31825
Subject(s) - materials science , tissue engineering , carbodiimide , polymer , cell adhesion , adhesion , biomedical engineering , surface modification , hyaluronic acid , chemical engineering , polymer chemistry , composite material , anatomy , medicine , engineering
New porous scaffolds, with a suitable hydrolytic and enzymatic degradation, useful for tissue engineering applications have been obtained by a carbodiimide mediated reaction between hyaluronan (HA) and a synthetic polymer with a polyaminoacid structure such as α,β‐polyaspartylhydrazide (PAHy). Scaffolds with a different molar ratio between PAHy repeating units and HA repeating units have been prepared and characterized from a chemical and physicochemical point of view. Tests of indirect and direct cytotoxicity, cell adhesion, and spreading on these biomaterials have been performed by using murine L929 fibroblasts. The new biomaterials showed a good cell compatibility and ability to allow cell migration into the scaffolds as well as spreading on their surface. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008