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Osteogenic activity of the mixture of chitosan and particulate dentin
Author(s) -
Park SunSik,
Kim SuGwan,
Lim SungChul,
Ong Joo L.
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31812
Subject(s) - chitosan , dentin , particulates , materials science , dentistry , composite material , chemistry , medicine , organic chemistry
To evaluate the healing effect of a mixture of chitosan and particulate dentin, a 8‐mm‐diameter critical size defect was created in the calvarium of 75 rats. The rats were divided into four experimental groups and a control group (no treatment). The defects in the experimental groups were grafted either with pig particulate dentin (group 1), a mixture of particulate dentin and plaster of Paris (group 2), particulate dentin and chitosan (group 3), or chitosan only (group 4). Rats in each group were sacrificed 2, 4, and 8 weeks after implantation. All experimental groups showed more new bone formation when compared to the control group. Additionally, all groups exhibited more bone growth at 8 weeks than at 4 weeks after implantation. It was concluded from this study that defects treated with particulate dentin powder–chitosan mixture may mediate an excellent effect on the formation of new bones. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008