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Micelles based on amphiphilic PCL‐PEO triblock and star‐shaped diblock copolymers: Potential in drug delivery applications
Author(s) -
Quaglia Fabiana,
Ostacolo Luisanna,
Nese Giuseppe,
Canciello Mariarosaria,
De Rosa Giuseppe,
Ungaro Francesca,
Palumbo Rosario,
La Rotonda Maria Immacolata,
Maglio Giovanni
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31804
Subject(s) - micelle , copolymer , nanocarriers , materials science , amphiphile , polymer chemistry , drug delivery , polymerization , ring opening polymerization , chemical engineering , organic chemistry , polymer , nanotechnology , chemistry , aqueous solution , composite material , engineering
In this work, the potential in drug nanodelivery of micelles made from poly(ϵ‐caprolactone) (PCL) and poly (ethyleneoxide) (PEO) copolymers with triblock and star‐diblock architectures was explored. Linear and 4‐arm star‐shaped PCL macromers with two or four OH end groups were prepared by ring‐opening polymerization of CL and condensed with α‐methoxy‐ω‐carboxy‐PEO. The resulting amphiphilic copolymers were characterized by 1 H NMR, size exclusion chromatography, and differential scanning calorimetry. Separate PCL and PEO crystalline phases were observed for both copolymers. Copolymers self‐assembled in water giving critical association concentrations in the range 0.010–0.023 mg/mL. Micelles with a size of 32–45 nm were prepared by dialysis and characterized for hydrodynamic diameter and surface charge. Their potential as nanocarriers in drug delivery applications was evaluated too. Micelles were nontoxic to both Red blood cells and HeLa cells. Complement activation experiments indicated that micelles can escape the reticuloendothelial system once intravenously injected. Finally, a different uptake on HeLa cells was found for micelles obtained from triblock and star‐shaped copolymers. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008