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Synthetic zeolites as a new tool for drug delivery
Author(s) -
Rimoli Maria G.,
Rabaioli Maria R.,
Melisi Daniela,
Curcio Annalisa,
Mondello Sandro,
Mirabelli Rosella,
Abignente Enrico
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31763
Subject(s) - ketoprofen , zeolite , thermogravimetric analysis , materials science , drug delivery , chemical engineering , adsorption , scanning electron microscope , drug carrier , infrared spectroscopy , nuclear chemistry , chromatography , organic chemistry , nanotechnology , chemistry , catalysis , composite material , engineering
Synthetic zeolites were studied in order to investigate their ability to encapsulate and to release drugs. In particular, a zeolite X and a zeolitic product obtained from a cocrystallization of zeolite X and zeolite A were examined. These materials were characterized by chemical analyses (ICP‐AES), X‐ray diffraction, nitrogen adsorption isotherm, scanning electron microscopy, laser diffraction, and infrared spectroscopy. Since ketoprofen was chosen as a model drug for the formulation of controlled‐release dosage forms, it was encapsulated into these two types of synthetic zeolites by a soaking procedure. Drug‐loaded matrices were then characterized for entrapped drug amount and thermogravimetric behavior. In both types of activated zeolites, the total amount of ketoprofen (800 mg) was encapsulated in 2 g of matrix. By using HPLC measurements, ketoprofen release studies were done at different pH conditions so as to mimick gastrointestinal fluids. The absence of release in acid conditions and a double phased release, at two different pH values (5 and 6.8), suggest that after activation these materials offer good potential for a modified release delivery system of ketoprofen. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008