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Selective binding of carcinoembryonic antigen using imprinted polymeric hydrogels
Author(s) -
Casey Brendan J.,
Kofinas Peter
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31757
Subject(s) - carcinoembryonic antigen , materials science , molecular imprinting , imprinting (psychology) , self healing hydrogels , copolymer , ethylene glycol , polymer chemistry , selectivity , organic chemistry , biochemistry , polymer , medicine , chemistry , catalysis , cancer , composite material , gene
A poly(allylamine hydrochloride) carcinoembryonic antigen‐imprinted hydrogel was synthesized using a water‐soluble crosslinker, ethylene glycol diglycidyl ether, to investigate its viability for protein recognition. The imprinting factor of the imprinted hydrogel toward carcinoembryonic antigen was found to be ∼5, while the imprinting factor of the imprinted hydrogel toward α‐fetoprotein was determined to be ∼2, suggesting selectivity and specificity toward the template protein. This work lays the foundation for the development of a novel line of imprinted hydrogel systems capable of protein recognition for diagnostic and therapeutic applications. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res 2008