Premium
Targeted folic acid‐PEG nanoparticles for noninvasive imaging of folate receptor by MRI
Author(s) -
Chen TingJung,
Cheng TsanHwang,
Hung YuChin,
Lin KueiTang,
Liu GinChung,
Wang YunMing
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31752
Subject(s) - folate receptor , materials science , folic acid , peg ratio , nanoparticle , magnetic resonance imaging , nuclear magnetic resonance , biomedical engineering , nanotechnology , medicine , radiology , cancer , physics , finance , cancer cell , economics
The surface of superparamagnetic iron oxide nanoparticles (SPIO) with different molecular weight of poly(ethylene glycol) (PEG) and folic acid (FA) were synthesized. The SPIO‐PEG‐FA nanoparticles are well‐dispersed and have good stability in various pH solutions. The lack of hysterestis and remanence at ambient temperatures is characteristic of superparamagnetic materials for SPIO‐PEG‐FA. The uptake by macrophage for SPIO‐PEG‐FA is lower than that of Feridex I.V. even at higher concentration. Internalization of SPIO‐PEG‐FA in targeted cells (KB cells) was observed by flow‐cytometric analysis and in vitro MR imaging. The intensity change of positive KB cell tumor (−20 to 25%) is significantly lower than that of negative HT‐1080 cell tumor from precontrast to postcontrast images of the tumor by in vivo MR imaging. These preliminary results demonstrated that SPIO‐PEG‐FA have the ability to target folate receptor. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 87A: 165–175, 2008