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Bone growth enhancement in vivo on press‐fit titanium alloy implants with acid etched microtexture
Author(s) -
Daugaard Henrik,
Elmengaard Brian,
Bechtold Joan E.,
Soballe Kjeld
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31748
Subject(s) - materials science , osseointegration , hydrofluoric acid , titanium , implant , dentistry , biomedical engineering , titanium alloy , composite material , alloy , metallurgy , medicine , surgery
Early bone ongrowth secures long‐term fixation of primary implants inserted without cement. Implant surfaces roughened with a texture on the micrometer scale are known to be osseoconductive. The aim of this study was to evaluate the bone formation at the surface of acid etched implants modified on the micro‐scale. We compared implants with a nonparticulate texture made by chemical milling (hydrofluoric acid, nitric acid) (control) with implants that had a dual acid etched (hydrofluoric acid, hydrochloric acid) microtexture surface superimposed on the primary chemically milled texture. We used an experimental joint replacement model with cylindrical titanium implants (Ti‐6Al‐4V) inserted paired and press‐fit in cancellous tibia metaphyseal bone of eight canines for 4 weeks and evaluated by histomorphometric quantification. A significant twofold median increase was seen for bone ongrowth on the acid etched surface [median, 36.1% (interquartile range, 24.3–44.6%)] compared to the control [18.4% (15.6–20.4%)]. The percentage of fibrous tissue at the implant surface and adjacent bone was significantly less for dual acid textured implants compared with control implants. These results show that secondary roughening of titanium alloy implant surface by dual acid etching increases bone formation at the implant bone interface. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008