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Spray‐dried lipid‐hyaluronan‐polymethacrylate microparticles for drug delivery in the peritoneum
Author(s) -
Domnina Yuliya A.,
Yeo Yoon,
Tse Julie Y.,
Bellas Evangelia,
Kohane Daniel S.
Publication year - 2008
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.31741
Subject(s) - peritoneum , hyaluronic acid , drug delivery , biocompatibility , biomedical engineering , drug , materials science , liposome , pharmacology , drug carrier , nanotechnology , surgery , medicine , anatomy , metallurgy
Application of controlled release technology to the peritoneum would allow for sustained drug levels. However, some polymeric systems either create adhesions, or rapidly exit the peritoneum; neither result is desirable. Here we have produced particles based on sphyngomyelin, a phospholipid that occurs naturally in the peritoneum, along with hyaluronic acid and the polymethacrylate Eudragit E100 (to modulate drug release). Particles with a low proportion of E100 (5% (w/w); “high SPM”) release albumin rapidly over 2 days, then more slowly; increasing the E100 to 20% (w/w; high “E100”) slowed drug release markedly. When injected in the murine peritoneum, high SPM particles were disseminated as free particles, without forming collections. There was a mild inflammatory response but no formation of adhesions. High E100 particles formed collections in all animals, with an intense inflammatory response. Even so, there were very few adhesions. These results suggest that microparticulate formulations can be produced that have acceptable drug‐releasing properties and are suitable for use in the peritoneum from the standpoint of biocompatibility. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res 2008